Silent Mutation in KISS1 and KISS1R and Unexplained Infertility

silent mutation in kiss1 and kiss1r and unexplained infertility

Kisspeptin, unexplained infertility and embryo implantation

Objective The primary objective of the study was to compare baseline KP levels in females with different causes of infertility and then correlate it with the risk of failure to conceive, preclinical abortion and pregnancy after intracytoplasmic sperm injection (ICSI). MaterialsAndMethods AA longitudinal cohort study was carried out from August 2014 till May 2015 recruiting one hundred and twent...

KISS1 and KISS1R expression in the human and rat carotid body and superior cervical ganglion

KISS1 and its receptor, KISS1R, have both been found to be expressed in central nervous system, but few data are present in the literature about their distribution in peripheral nervous structures. Thus, the aim of the present study was to investigate, through immunohistochemistry, the expression and distribution of KISS1 and KISS1R in the rat and human carotid bodies and superior cervical gang...

Unexplained Infertility

Changes in Methylation Patterns of Kiss1 and Kiss1r Gene Promoters Across Puberty

The initiation of mammalian puberty is underpinned by an increase in Kisspeptin (Kiss1) signaling via its receptor (Kiss1r/GPR54) on gonadotropin-releasing hormone (GnRH) neurons. Animals and humans with loss-of-function mutations in Kiss1 or Kiss1r fail to go through puberty. The timing of puberty is dependent on environmental factors, and malleability in puberty timing suggests a mechanism th...